Education: Bachelor of Medicine, Bachelor of Surgery MBBCh. Mansoura Manchester Program for Medical Education, Mansoura University, Egypt, 2013
Hometown: Mansoura, Egypt
Thesis adviser: Diomedes Logothetis, Ph.D., Physiology and Biophysics
Research interests: Molecular determinants of positive allosteric modulators (PAMs) of metabotropic glutamate receptor 2 (mGluR2)
Personal bio: I got my medical degree early in 2013 and moved to the US a couple of months later to do pursue my graduate studies in neuroscience before going to residency. After joining the VCU neuroscience program, I quickly realized I’m interested in neuropharmacology, cell signaling, and electrophysiology. I joined the lab of Dr. Diomedes Logothetis where I learned how to utilize electrophysiological techniques to study G-protein coupled receptors (GPCRs). In my free time, I enjoy working out, hiking, and finding new bars/restaurants with live music.
Younkin J*, Gaitonde SA*, Ellaithy A*, Vekariya R, Baki L, Moreno JL, Shah S, Hideshima KS, Eltit JM, González-Maeso, J Logothetis DE, Dukat M, Glennon RA. Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists. ACS Chemical Neuroscience. 2016;7(9):1292-9. (* Co-First/Equal authorship)
Ellaithy A, Younkin J, Gonzalez-Maeso J, Logothetis DE. Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment. Trends Neurosci. 2015; 38:506-16.
Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE. G protein-coupled receptor signaling to kir channels in Xenopus oocytes. Curr Pharm Biotechnol. 2014;15:987-95.
Salama M, Helmy B, El-Gamal M, Reda A, Ellaithy A, Tantawy D, Mohamed M, El-Gamal A, Sheashaa H, Sobh M. Role of L-thyroxine in counteracting rotenone induced neurotoxicity in rats. Environ Toxicol Pharmacol. 2013;35:270-7.
Salama M, Ellaithy A, Helmy B, El-Gamal M, Tantawy D, Mohamed M, Sheashaa H, Sobh M, Arias-Carrión O. Colchicine Protects Dopaminergic Neurons in a Rat Model of Parkinson’s Disease. CNS Neurol Disord Drug Targets. 2012;11:836-43.
Conferences and Abstracts:
Ellaithy A, Xu Y, Kawano T, Gonzalez-Maeso J, Logothetis D. Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2. Poster presentation at Chemistry and Pharmacology of Drug Abuse (CPDA) conference, Boston, Massachusetts, August 2017.
Xu Y, Ellaithy A, Kawano T, Gonzalez-Maeso J, Logothetis D. Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2. Biophysical Journal. 2017;112(3):530a. Poster presentation at Biophysical society meeting, New Orleans, Louisiana, February 2017.
Ellaithy A, Younkin J, Baki L, Logothetis DE. A positive allosteric modulator of the metabotropic glutamate 2 receptor alters 5-HT2A receptor signaling in a heteromeric complex. Poster presentation at Biophysical society meeting, Baltimore, Maryland, February 2015.
Ellaithy A, Helmy B, Salama M. Does Colchicine possess a neuroprotective effect in Parkinson’s disease? Poster presentation at University Medical Center Groningen ISCOMS, June 2012, Netherlands.